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      1. Global
        全球營養屋

        營養屋實驗室

           營養屋創始人陳耀明博士,學貫中西,領銜組建了營養屋實驗室。實驗室長期致力于前沿醫藥和營養學的研究,發表了大量研究論文,擁有多項專利。

           陳博士帶領一行科學家,秉承“營養促進健康”理念,運用現代醫學研發技術,將創新的研究成果、優質的特色資源經過嚴謹的配方論證和功效試驗篩選,研發優選出多種復合配方營養保健品。

        營養屋科學家論文精選

        1. 2'-Deoxyisoinosine and 8-Aza-7-deaza-2'-deoxyisoinosine Form Base Pairs with 2'-   Deoxycytidine and 2'Deoxyisocytidine, Y. Chen,G.Becher, F. Seela, Nucleosides &   Nucleotides, submitted.

        2. The Sugar Conformation of 8-Azaz-1,3-dideaza-2'-deoxyadenosine in Solid State and Solution, Y. Chen, F. Seela, in Preparation.

        3. 7-Deazapurine Oligodeoxyribonucleotides: The Effects of 7-Deaza-8-methylguanine on DNA-Structure and Stability, F. Seela, Y. Chen, C.Mittelbach, Helv. Chim. Acta. 1998, 81, 570.

        4. Synthesis of 2',3'-Didehydro-2',3'-Dideoxyisoinosine and Oxidation of Fluorescent 2-Hydroxypurine Nucleosides by Xanthine Oxidase, F.Seela, Y. Chen, M. Sauer,Nucleosides & Nucleotides 1998, 17, 39.

        5. Regioselectivity of the Mannich Reaction on Pyrrolo[2,3-d]pyrimidine Nucleosides Related to 7-Deaza -2'-deoxyadenosines or 7-Deaza-2'-deoxyguanosines, F. Seela, Y. Chen, M. Zulauf, Synthesis 1997, 1067.

        6. Methylated DNA: The Influence of 7-Deaza-7-methylguanine on the Structure and Stabilityof Oligonucleotides, F. Seela, Y. Chen, Helv. Chim. Acta 1997, 80, 1073.

        7. Steric and stereoelectronic Effect of 7-deazapurine Bases on the Surgar Confomation of Nucleosides, H. Rosemeyer, N. Ramzaeva,M. Zulauf, H. Thomas, Y. Chen, C. Mittelbach, F. Seela, Nucleosides & Nucleotides 1997, 16, 1447.

        8. 7-Nitro-7-deaza-2'-deoxyadenosine and 8-Methyl-7-deaza-2'-deoxyguanosine:Pyrrolo[2,3-d]pyrimidine Nucleosides with Different Sugar Conformations, F. Seela, H. Rosemeyer, M. Zulauf, Y. Chen, G. Kastner, H. Reute,Liebigs. Ann. Chem. 1997, 2525.

        9. Oligonucleotides Containing 7- or 8-Methyl-7-deazaguanine: Steric Requirements of Major Groove Substituents on the DNA Structure,F. Seela, Y. Chen, Chem. Commun. 1996, 2263.

        10. Synthesis and Application of Novel Nucleoside Phosphonates and Phosphoramidites Modified at the Base Moiety, F. Seela, Y. Chen,A. Melenewski,H. Rosemeyer, C. Wei, Acta Biochimica Polonica. 1996, 43, 45.

        11. Oligonucleotides Containing 7-Deazaguanine: the Role of 7- and 8-Methyl Groups During the B-Z Transition of DAN, F. Seela, Y. Chen,Collect. Czech. Chem. 1996, 61, 112.

        12. Oligonucleotides Containing Fluorescent 2'-Deoxyisoinosine: Solid-Phase Synthesis and Duplex Stability, F. Seela, Y. Chen, NucleicAcids Res. 1995, 23, 2499.

        13. Oligonucleotide Duplex Stability Controlled by the 7-Substituents of 7-Deazaguanine Bases, F. Seela, N. Ramzaeva, Y. Chen, Bioorg.Med. Chem. Lett. 1995, 5, 3049.

        14. 2'-Deoxyisoinosine: Synthesis of a Highly Fluorescent Nucleoside and Its Incorporation into Oligonucleotides, F. Seela, Y. Chen,Nucleosides & Nucleotides 1995, 14, 863.

        15. Synthesis of 2'-Deoxyisoinosine and Related 2'-Deoxyribonucleosides”, F. Seela, Y. Chen, U. Bindig, Z. Kazimierczuk, Helv. Chim.Acta 1994, 77, 194.

        16. Synthesis of N-(4-Carbethoxy-4-Substituted Butyl)-N-Substituted Glycines, and the Evaluation of their Angiotensin Converting EnzymeInhibitors (ACEI) Activities, Y. Chen, C.-Y. Cai, K.-S. Gong, Acta Pharmaceutica Sinica 1989, 24, 887.


        營養屋科學家專利精選


        1. Purine analog nucleoside and nucleotide compounds.Seela, Frank; Bourgeouis,Werner; Gumbiowski, Rainer; Roling, Angelika; Rosemeyer, Helmut; Mertens, Alfred; Zilch, Harald;Konig, Bernhard; Koch, Edith. (Boehringer Mannheim GmbH, Mannheim, Germany), US-Patent 5,446,139 1995.

        2. Desazapurin-Nucleosid-Derivate, Verfahren zu deren Herstellung sowie deren Verwendung bei der Nucleinsure-Sequenzierungsowie als antivirale MittelSeela, F.; Muth, H.-P.; Kaiser, K.; Bourgeois, W.; Mühlegger, K.; von der Eltz, H.; Batz, H.-G. (Boehringer Mannheim GmbH,Mannheim, Germany), EU-Patent 0 286 028 B1 1995.

        3. Nucleosid-Derivate und deren Verwendung als ArzneimittelSeela, F.; Bourgeois, W.; Gumbiowski, R.; Roeling, A.; Rosemeyer, H.; Mertens, A.; Zilch, H.; Konig, B.; Koch, E. (BoehringerMannheim GmbH, Mannheim, Germany), EU-Patent 0 666 269 A2 1995.

        4. 7-Deaza-2’-deoxyguanosine nucleotides and nucleic acids analogs thereofSeela, F. (Boehringer Mannheim GmbH, Mannheim, Germany), US-Patent 5,480,980 1996.

        5. Modified oligonucleotides, their preparation and their use.Seela, Frank; Thomas, Horst. (Hoechst Aktiengesellschaft, Germany), US-Patent 5,844,106 1998.

        6. Nucleotide monomers containing 8-azapurin bases or a derivative thereof, their preparation and their use in makingmodified oligonucleotidesSeela, F, Lampe S. (Hoechst AG, Frankfurt, Germany), US-Patent 5,789,562 1998.

        7. Synthesis of 7-deaza-2’deoxyguanosine nucleotidesSeela, F. (Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 5,990,303 1999.

        8. Modified oligonucleotides, their preparation and their useSeela, F.; Lampe, S. (Hoechst AG, Frankfurt, Germany), US-Patent 6,066,720 2000.

        9. Modified oligonucleotides, their preparation and their useSeela, Frank; Thomas, Horst (Aventis Pharma Deutschland GmbH, Frankfurt am Main, Germany), US-Patent 6,150,510 2000.

        10. Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containingthem and the use thereof for nucleic acid sequencing and as antiviral agents.Seela, Frank; Muth, Heinz-Peter; Kaiser, Klaus; Bourgeois, Werner; Mühlegger, Klaus, von der Eltz, Herbert, Batz, Hans-Georg.(Roche Diagnostics GmbH, Mannheim, Germany), US-Patent 6,211,158 B1 2001.

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